The seven-seat people carrier, a new model launched in 2010 to replace the ageing previous generation, is one of the most decorated in the UK after the latest title.
Auto Express Acting Editor, Graham Hope, said: "These machines are the multi-tools of the automotive world and the Seat is both incredibly practical and easy to live with.
"A smart exterior and classy interior help to seal the deal, while attractive prices and low running costs take care of your wallet."
The Seat Alhambra has previously been praised for its car-like drive – a rarity in a large, tall car such as an MPV.
Based on the almost-identical Volkswagen Sharan, the Alhambra is much cheaper with prices starting from as little as £23,000.
It is also more modern inside, with an updated interior and flexible seating ensuring any configuration of passengers and luggage can be derived from the seven-seat car.
This, coupled with VW engines including a single 1.4-litre petrol engine and two 2.0-litre diesels in 138bhp and 168bhp configurations, has propelled the Seat Alhambra to the top of the MPV awards charts in recent months.
Prior to the Auto Express award, the car has also received the ‘Best MPV’ honour from prestigious UK magazines such as What Car?, Fleet World and Diesel Car, as well as CarBuyer.co.uk.
Seat UK Head of Marketing, Steve Robertson, said: "I can’t recall a time when a Seat model has scooped so many top awards in the space of less than a year, which I hope tells would-be buyers all they need to know about the quality, value and genuine class of our new seven-seat Alhambra."